Press Releases

  1. Resolve Biosciences Launches Commercial Molecular Cartography™ Services to Provide Scientists with Highest-Resolution View of Subcellular Gene Expression. June 2, 2021
  2. Resolve Biosciences Announces Initial Results from Early Access Collaborations with Scientists Leading the Next Generation of Subcellular Spatial Analysis. Feb. 22, 2021
  3. Resolve Biosciences Launches New Era in Single-Cell Spatial Analysis. Dec. 10, 2020

Resolve Biosciences Launches Commercial Molecular Cartography™ Services to Provide Scientists with Highest-Resolution View of Subcellular Gene Expression

Company expands global footprint with opening of US facility and appoints industry veteran Chris Barbazette to lead rapidly growing commercial organization

MONHEIM AM RHEIN, Germany, and SAN JOSE, Calif. – June 2, 2021 – Resolve Biosciences today announced the commercial launch of its groundbreaking Molecular Cartography™ service offering to provide scientists with the highest-resolution view of subcellular gene expression. Through this new service offering, customers in North America and Europe will be able to submit their samples of interest for analysis and receive data back from Resolve’s technical team. To help meet the significant global demand for its next-generation spatial analysis technology, Resolve is expanding capabilities in Europe and has opened a North American facility in San Jose, Calif. In addition, Resolve has appointed Chris Barbazette as Chief Commercial Officer to lead the company’s growing sales and marketing operations.

Under development since 2016, Resolve’s Molecular Cartography platform consists of proprietary, highly multiplexed, single-molecule detection technology to measure transcriptomic activity with full spatial context at subcellular resolution. During the past year, the technology has demonstrated groundbreaking capabilities in several high-profile early access collaborations to better understand human brain development, cell type evolution, and how the SARS-CoV-2 infection affects neighboring cells over time. Unlike other spatial analysis techniques, the Resolve platform provides the required sensitivity and specificity to elucidate a cell’s complex transcriptional landscape. The technology generates deep contextual data sets that illuminate molecular interactions while preserving sample tissue for future analysis.

“We believe the power of spatial biology lies in enabling a deeper understanding of biological mechanisms, interactions, and complexity,” said Jason T. Gammack, Co-founder and CEO of Resolve Biosciences. “After the resounding success of our early access program, we are now delivering our innovative Molecular Cartography services to leading institutions throughout the US and Europe.”

Global Footprint and Commercial Operations Expansion
To help support the global demand for its Molecular Cartography services, Resolve is rapidly expanding its team and opening a new state-of-the-art office and laboratory in San Jose. The new facility will augment the company’s German headquarters and provide regional support to the company’s growing customer base in North America. Chris Barbazette, who brings a proven track record of introducing disruptive technologies and directing successful global commercial organizations, will oversee the new facility and commercial operations around the world.

Mr. Barbazette previously held senior commercial positions at GenapSys, Agendia, and Affymetrix. As Senior Vice President of Global Commercial Operations at Affymetrix, he was responsible for building a robust worldwide distribution network that brought the latest genotyping and gene expression solutions to customers in more than 40 countries.

“Resolve Biosciences has the right team and technology platform to lead the next generation of genomic analysis. Molecular Cartography provides high-resolution spatial context and adds a valuable new dimension to scientific research that enables a better understanding of biological mechanisms and functions,” said Mr. Barbazette. “I’m looking forward to supporting our growing customer base and empowering them with tools to provide insights that will transform life sciences research and, eventually, clinical diagnostics.”

Scientists interested in learning more about the innovative Molecular Cartography services can contact the Resolve team.

About Resolve Biosciences

Resolve Biosciences is applying the power of Molecular Cartography to enable scientists to gain new insights based on the highest-resolution view of spatial biology. The platform features the company’s proprietary, highly multiplexed, single-molecule detection technology, which offers full spatial context at subcellular resolution, all in a fully automated workflow that preserves the sample tissue. The Molecular Cartography technology offers unparalleled sensitivity and specificity that helps scientists detect individual transcripts and rare signals to interpret fundamental biology and rapidly advance the understanding of complex biological questions in critical fields such as oncology, neuroscience, and infectious disease. The technology has been under development since 2016 and is currently available through Resolve Biosciences’ commercial service laboratory. Resolve Biosciences is privately held and based in Monheim am Rhein, Germany, with a North American facility and laboratory in San Jose, Calif. For additional information, visit www.resolve-biosciences.com.

Resolve Biosciences, the Resolve Biosciences logo, and Molecular Cartography are trademarks of Resolve Biosciences Inc.

Media Contact

Andrew Noble
+1 (415) 722-2129
andrew@bioscribe.com


Resolve Biosciences Announces Initial Results from Early Access Collaborations with Scientists Leading the Next Generation of Subcellular Spatial Analysis

The power and resolution of the Molecular Cartography™ platform is illuminating important cellular interactions in COVID-19 pathology, neurology, and developmental biology research

MONHEIM AM RHEIN, Germany – Feb. 22, 2021 – Resolve Biosciences, the pioneer in Molecular Cartography™, today announced initial results from several prominent early access collaborations with leading laboratories across Europe. Teams of scientists are currently using the groundbreaking subcellular spatial analysis technology to help resolve daunting challenges in COVID-19 pathology, neurology, and developmental biology research.

SARS-CoV-2-transcript
SARS-CoV-2 transcripts of the nucleocapsid protein (shown in yellow) are predominantly found close to the cell nucleus. Interestingly, some cells show a polar localization of SARS-CoV-2 transcripts (red arrows). Transcripts of 80 other genes (marked in different colors) are distributed throughout the cell. The Resolve Biosciences Molecular Cartography™ technology enabled scientists to compare infected and non-infected cells to understand subcellular gene regulation and how the infection affects neighboring cells over time.

Under development since 2016, Resolve’s Molecular Cartography platform features the company’s proprietary, highly multiplexed, single-molecule detection technology to provide the highest-resolution view of subcellular transcriptomic activity. Unlike other spatial analysis techniques, the Resolve platform provides the required sensitivity, specificity, and workflow convenience to elucidate the cell’s complex transcriptional landscape. The technology generates deep contextual data sets that illuminate molecular interactions at subcellular resolution while preserving the sample tissue for future analysis.

The Resolve Molecular Cartography platform has been available through an oversubscribed early access program during the past year. Initial findings from several of the high-profile projects include:

  • SARS-CoV-2 Infection and Inflammatory Response — Medical University of Graz, Austria
    The laboratory led by Kurt Zatloukal, MD, Professor of Pathology and Head of the Diagnostic and Research Center for Molecular Biomedicine, is using the Molecular Cartography platform to study the molecular pathology behind SARS-CoV-2 infection and the subsequent inflammatory response on the mRNA level that leads to severe disease. The Resolve technology offers the ability to explore the distribution of infected cells, their morphology, and molecular activity at the same time. The team analyzed different cell culture systems to compare the transcriptomic activity of more than 80 genes in infected cells and non-infected cells, explore how cells react to changes in gene expression upon viral infection, analyze the exact position of transcripts within cells, and investigate how the antiviral host response can trigger tissue damage. The initial results have provided a better understanding of subcellular gene regulation and how the infection affects neighboring cells over time.
  • Human Brain Development — MRC Laboratory of Molecular Biology, Cambridge, UK
    Madeline A. Lancaster, PhD, Group Leader in the Cell Biology Division, and her team are applying the power of Molecular Cartography to brain organoids to unravel the spatial logic of neural tissue development. Since the technology reliably captures spatiotemporal gene expression, researchers can study key aspects of human brain function and development in vitro. The team used the technology to detect and quantify expression with ultra-high sensitivity, showing 100 gene transcripts simultaneously at subcellular resolution. The initial results suggest that the spatial distribution of mRNA molecules for outer radial glia (oRG) cell markers is not confined to the outer subventricular zone but rather is spread throughout the whole proliferative ventricular zone. This observation highlights the necessity to look for more specific oRG markers to be applied in the context of brain organoids.
  • Retina Gene Expression and Cell Type Evolution — University College London, UK
    Ryan MacDonald, PhD, Biotechnology and Biological Sciences Research Council David Phillips Fellow and Lecturer at the Institute of Ophthalmology, and his colleagues are using Molecular Cartography technology to better understand how a healthy retina develops and changes with advancing age. Scientists were able to visualize the spatial expression of 48 genes simultaneously in the same zebrafish sample to observe the development of different cell types using specific marker genes in the retina. Then by visualizing gene expression changes over the entire lifespan, specifically within the support cells called glia, they were able to identify candidate genes that are dysregulated in the aging retina and potentially underlie progressive neuronal degeneration and vision loss.

“Thanks to its exquisite resolution, the technology from Resolve Biosciences allows us to detect specific gene expression patterns in SARS-CoV-2 that we could not see with existing RNA sequencing or single-cell RNA-seq technologies,” said Prof. Zatloukal. “Since the Resolve workflow provides spatial information at subcellular resolution and still preserves the tissue integrity, we see clear clinical opportunities with this approach moving forward.”

“Over the past year, Resolve Biosciences has had the privilege of working with many of the true visionaries of single-cell and spatial biology,” said Jason T. Gammack, Co-founder and CEO of Resolve Biosciences. “We are grateful for their engagement and feedback, and proud that they were able to gain new insights that were not possible with alternative approaches. We look forward to empowering more scientists around the world with this same ability to rapidly advance the understanding of complex biology with our novel Molecular Cartography platform.”

Resolve Biosciences is now expanding its early access program globally. Scientists interested in learning more about how to access and apply the power of its innovative Molecular Cartography technology can contact the company. 

About Resolve Biosciences

Resolve Biosciences is applying the power of Molecular Cartography to enable scientists to gain new insights based on the highest-resolution view of single-cell spatial biology. The platform features the company’s proprietary, multiplexed, single-molecule detection technology, which offers full spatial context at subcellular resolution, all in a workflow that preserves the sample tissue. The Molecular Cartography technology offers unparalleled sensitivity and specificity that helps scientists detect individual transcripts and rare signals to interpret fundamental biology and rapidly advance the understanding of complex biological questions in critical fields such as oncology, neuroscience, and infectious disease. The technology has been under development since 2016 and is currently available through an oversubscribed early access program. Resolve Biosciences is privately held and headquartered in Monheim, Germany. For additional information, visit www.resolve-biosciences.com.

Resolve Biosciences, the Resolve Biosciences logo, and Molecular Cartography are trademarks of Resolve Biosciences Inc.

Media Contact

Andrew Noble
+1 (415) 722-2129
andrew@bioscribe.com


Resolve Biosciences Launches New Era in Single-Cell Spatial Analysis

Company announces $24 million Series A financing and appoints Jason T. Gammack as CEO to accelerate development and commercialization of Molecular Cartography™ platform

MONHEIM AM RHEIN, Germany – Dec. 10, 2020 – Resolve Biosciences, the pioneer in Molecular Cartography™, announced the completion of a $24 million Series A financing round and the appointment of Co-founder Jason T. Gammack as Chief Executive Officer.

Detection of 500,000 mRNA Transcripts from 100 different genes in a mouse cortex tissue using Resolve Biosciences’ Molecular Cartography™ platform.
Credentials: Resolve Biosciences, Courtesy of Araks Martirosyan (Matthew Holt lab, VIB-KU Leuven, Belgium)

The company’s Molecular Cartography platform is a groundbreaking multi-analyte and highly multiplex spatial analysis technology that enables scientists to resolve the most daunting biological challenges in areas such as oncology, neuroscience, and infectious disease. It produces deep contextual data sets that illuminate molecular interactions at subcellular resolution, while preserving the sample tissue. The initial applications of Resolve’s Molecular Cartography platform deliver the highest-resolution view of transcriptomic activity and provide the ability to interrogate hundreds of genes in a single run. Future solutions will add DNA, protein, and metabolomic data layers. Unlike current approaches, Resolve’s technology provides the required sensitivity, specificity, and workflow convenience to elucidate the cell’s complex transcriptional landscape.

Series A Financing

The Series A financing round was led by PS Capital Management and MasterMind Advisory Services and included participation from Alafi Capital, John Shoffner, and High Tech GrĂĽnderfonds. The company will use the proceeds to accelerate product development and drive industry adoption of its Molecular Cartography technology.

“Molecular Cartography creates a new dimension of spatial analysis, which will soon expand the frontiers of modern molecular biology. Our innovative solution enables valuable scientific insights that far exceed the reach of legacy spatial biology technologies,” said Peer M. Schatz, Chairman and Co-founder of Resolve Biosciences. “Jason is an accomplished leader in the field of advanced genomics, and I’m looking forward to working with him again to help Resolve Biosciences transform the future of life sciences research and clinical diagnostics.”

CEO Appointment

Jason T. Gammack brings more than 25 years of life sciences industry experience and has developed successful product and customer engagement strategies for some of its preeminent biotechnology brands. He recently served as Chief Commercial Officer at Inscripta, where he oversaw sales, marketing, business development, and customer support for the company’s CRISPR-enabled Onyx™ Digital Genome Engineering platform. Before that, he was Vice President of the Life Science Business at QIAGEN, where he led the life science portfolio and go-to-market strategy. Earlier in his career, Gammack developed commercialization growth strategies at Ingenuity Systems, a leading bioinformatics company acquired by QIAGEN in 2013. He has also held senior leadership roles at Sigma-Aldrich, Invitrogen/Life Technologies, Affymetrix, and Promega Corporation.

“Resolve Biosciences’ pioneering Molecular Cartography platform powers novel insights by enabling scientists to gain the highest-resolution view of subcellular gene expression activity,” said Gammack. “Together with our talented team of scientists and investors, we are poised to lead the next generation of single-cell analysis and support scientists around the world as they apply the latest advances of our Molecular Cartography technology platform to solve the most complex biological questions.”

About Resolve Biosciences

Resolve Biosciences is applying the power of Molecular Cartography to enable scientists to gain new insights based on the highest-resolution view of single-cell spatial biology. The platform features the company’s proprietary, multiplexed, single-molecule detection technology, which offers full spatial context at subcellular resolution, all in a workflow that preserves the sample tissue. The Molecular Cartography technology offers unparalleled sensitivity and specificity that helps scientists detect individual transcripts and rare signals to interpret fundamental biology and rapidly advance the understanding of complex biological questions in critical fields such as oncology, neuroscience, and infectious disease. The technology has been under development since 2016 and is currently available through an oversubscribed early access program. Resolve Biosciences is privately held and headquartered in Monheim, Germany. For additional information, visit www.resolve-biosciences.com.

Resolve Biosciences, the Resolve Biosciences logo, and Molecular Cartography are trademarks of Resolve Biosciences Inc.

Media Contact

Andrew Noble
+1 (415) 722-2129
andrew@bioscribe.com

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